Toxicoepigenetics

    The epigenome is responsive to a wide range of environmental factors, including toxicant exposure, diet, stress, and socioeconomic circumstances. Traditional toxicological paradigms have relied on factors such as age, genetic polymorphisms, and disease status to identify variability in responsiveness to environmental toxicant exposure; however, these factors are neither sufficient to faithfully identify differentially responsive individuals, nor are they modifiable factors that can be leveraged to mitigate adverse health effects of toxicant exposures. An individual's epigenome, on the other hand, can be shaped by interactions with chemical and nonchemical aspects of the environment, giving it potential as a tool for the promotion of public health. The field of toxicoepigenetics is fastly evolving to provide novel insights into the mechanisms underlying exposure‚Äźrelated susceptibility and disease.

 

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