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8th World Congress on Epigenetics and Chromosome, will be organized around the theme “Advanced Techniques of Epigenetics & Oncology”

Epigenetics 2021 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Epigenetics 2021

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Epigenetics is that the study of heritable changes in natural phenomenon (active versus inactive genes) i.e. an adjustment in phenotype without an adjustment in genotype. An epigenetic change is also a natural & characteristic occurrence yet can likewise be plagued by some factors including age, the environment/lifestyle, and illness state. Alternately, epigenetic change can have all the more harmful impacts which will bring illnesses, disease. Major areas of Epigenetics are.
 

  • Track 1-1Clinical epigenetics
  • Track 1-2Developmental Epigenetics
  • Track 1-3Nutritional Epigenetics
  • Track 1-4Neuronal Epigenetics
  • Track 1-5Epigenetics Alteration
  • Track 1-6Behavioral epigenetics
  • Track 1-7Animal Epigenetics

Epigenetics focuses on processes that regulate how and when certain genes are turned on and turned off, while epigenomics pertains to analysis of epigenetic changes across many genes in a cell or entire organism.

 

  • Track 2-1DNA methylation
  • Track 2-2Chromatin
  • Track 2-3Non-coding RNAs

A brain tumor occurs when abnormal cells form within the brain There are two main types of tumors cancerous (malignant) tumors and benign (non-cancerous) tumors Cancerous tumors can be divided into primary tumors, which start within the brain, and secondary tumors, which most commonly have spread from tumors located outside the brain, known as brain metastasis tumors All types of brain tumors may produce symptoms that vary depending on the part of the brain involveds 

  • Track 3-1Meningiomas
  • Track 3-2Pituitary adenomas
  • Track 3-3Nerve sheath tumors
  • Track 3-4Gliomas

By the tip of the last century, it absolutely was known that DNA by itself doesn't determine all characteristics of an organism, including humans. The environment, stress one perceives, and nutrition, to call some, play a big part in determining the response of an organism, the utmost amount because the DNA itself. Thus, it's known now that both nature and nurture play equally important roles within the responses observed both at the cellular and organism levels.

  • Track 4-1Nutritional
  • Track 4-2Tobacco Smoke
  • Track 4-3Physical Activity
  • Track 4-4Alcohol
  • Track 4-5Pollutans
  • Track 4-6Emotional

Ranges of epigenetic idea affect our genetic programme. The inter-generational transmission of epigenetic marks is supposed to manage via four principal means dramatically differ in their information content: DNA methylation, histone modifications, microRNAs and nucleosome positioning.
 

 

  • Track 5-1Role in embryogenesis
  • Track 5-2Role in infertility
  • Track 5-3Role in assisted reproductive technology
  • Track 5-4Transgenerational epigenetic inheritance

Gene mapping describes the methods used to identify the locus of a gene and the distances between genes Gene mapping can also describe the distances between different sites within a gene. The essence of all genome mapping is to place a collection of molecular markers onto their respective positions on the genome.

  • Track 6-1Genetic mapping
  • Track 6-2In gene mapping
  • Track 6-3Physical mapping

Although brain tumours are rare compared with other malignancies, they are responsible, in many cases, for severe physical and cognitive disability and have a high case fatality rate. The diagnosis is made by a combination of imaging and histological examination of tumour specimen. Contrast-enhanced MRI is the gold standard imaging modality and provides highly sensitive anatomical information about the tumour

  • Track 7-1Pilocytic astrocytoma
  • Track 7-2Pilomxoid astrocytoma
  • Track 7-3Subependymal giant cell astrocytoma
  • Track 7-4Pleomorphic xanthoastrocytoma

A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs

  • Track 8-1RNA polymerase, together with one or more general transcription factors, binds to promoter DNA
  • Track 8-2RNA polymerase generates a transcription bubbleRNA polymerase adds RNA nucleotides
  • Track 8-3RNA sugar-phosphate backbone forms with assistance from RNA polymerase to form an RNA strand
  • Track 8-4Hydrogen bonds of the RNA–DNA helix break, freeing the newly synthesized RNA strand

Structural inheritance is an often-neglected form of nongenetic inheritance. This is in contrast to the transmission of digital information such as is found in DNA sequences, which accounts for the vast majority of known genetic variation. Structural inheritance was discovered by Tracy Sonneborn, and other researchers, during his study on protozoa in the late 1930

  • Track 9-1Multilevel Inheritance.
  • Track 9-2Single Inheritance
  • Track 9-3Hierarchical Inheritance.
  • Track 9-4Hybrid Inheritance.
  • Track 9-5Hybrid Inheritance.

nucleosome positioning” broadly to indicate where nucleosomes are located with respect to the genomic DNA sequence. Although nucleosome positioning is a dynamic process, sequencing-based mapping approaches identify the positions of individual nucleosomes in a single cell at a specific time.

  • Track 10-1Nucleosome positioning is strongly affected byDNA sequence
  • Track 10-2Poly tracts are important for nucleosome depletion
  • Track 10-3Aspects of positioning not determined by DNA sequence

Since Mendel, studies of phenotypic variation and disease risk have emphasized associations between genotype and phenotype among affected individuals in families and populations. Although this paradigm has led to important insights into the molecular basis for many traits and diseases, most of the genetic variants that control the inheritance of these conditions continue to elude detection.

 

  • Track 11-1Enviromental influences
  • Track 11-2Genetic factors
  • Track 11-3Gene-environment interactions
  • Track 11-4Frequency, magnitude & persistence

A nearly universal mechanism of epigenetic signalling is DNA methylation. In bacteria, DNA methylation has roles in genome defence, chromosome replication and segregation, nucleoid organization, cell cycle control, DNA repair and regulation of transcription

 

  • Track 12-1Techniques for DNA methylation detection
  • Track 12-2DNA replication initiation
  • Track 12-3Methyl-directed mismatch repair
  • Track 12-4Dam Methyltransferase in escherichia Coli

Understanding epigenetic processes holds immense promise for medical applications. Advances in Machine Learning (ML) are critical to realize this promise. Previous studies used epigenetic data sets associated with the germline transmission of epigenetic transgenerational inheritance of disease and novel ML approaches to predict genome-wide locations of critical epimutations.

  • Track 13-1Machine learning and epigenetics
  • Track 13-2Machine learning in biological datasets

Epigenetics is changing the widely accepted linear conception of genome function by explaining how environmental and psychological factors regulate the activity of our genome without involving changes in the DNA sequence. Research has identifi ed epigenetic mechanisms mediating between environmental and psychological factors that contribute to normal and abnormal behavioral development

 

  • Track 14-1Epigenetics of psychopathology: The case of schizophrenia
  • Track 14-2The infl uence of social environment on the epigenome
  • Track 14-3Conceptual implications
  • Track 14-4Behavioral epigenetics: how the environment ‘gets into the mind’

Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer. A medical professional who practices oncology is an oncologist Cancer survival has improved due to three main components: improved prevention efforts to reduce exposure to risk factors improved screening of several cancer and improvements in treatment.

  • Track 15-1Medical oncology:
  • Track 15-2Surgical oncology:
  • Track 15-3Radiation oncology

The recent development of high-throughput technologies has led to an explosion of biological data and has enabled mining biomarkers and drug targets in a more systematic way. Bioinformatic and biostatistical approaches are skilled at dealing with large data sets and therefore widely used in mining disease biomarkers and drug targets in this “omic” era.

  • Track 16-1Clinical material
  • Track 16-2ACPA-positive healthy
  • Track 16-3Sampling and DNA extraction
  • Track 16-4DNA preparation and CHARM

Computational modeling is the use of computers to simulate and study complex systems using mathematics, physics and computer science. A computational model contains numerous variables that characterize the system being studied. Simulation is done by adjusting the variables alone or in combination and observing the outcomes. Computer modeling allows scientists to conduct thousands of simulated experiments by computer.

 

  • Track 17-1Modeling infectious disease spread to identify effective interventions
  • Track 17-2Tracking viral evolution during spread of infectious disease.
  • Track 17-3Transforming wireless health data into improved health and healthcare.
  • Track 17-4Human and machine learning for customized control of assistive robots.

Chromatin analysis is the study of the structure or function of chromatin. Chromatin is made up of proteins (mainly histones) and genomic DNA packed inside the nuclei of eukaryotic cells; its architecture and chemical modifications affect genome structure, integrity and gene regulation Moreover, chromatin remodeling occurs during development and as the result of treatments. The assays below are used to study chromatin structure.

 

  • Track 18-1ChIP-chip
  • Track 18-2ChIP-Seq
  • Track 18-3ChIP-exo
  • Track 18-4ChIA-PET

Proteins control all biological systems in a cell, and while many proteins perform their functions independently, the vast majority of proteins interact with others for proper biological activity. Characterizing protein–protein interactions through methods such as co-immunoprecipitation pull-down assays, crosslinking, label transfer, and far–western blot analysis is critical to understand protein function and the biology of the cell.

 

  • Track 19-1Protein sequence and structure
  • Track 19-2Evolutionary history and conserved sequences
  • Track 19-3Expression profile
  • Track 19-4Post-translational modifications
  • Track 19-5Interactions with other proteins

Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. Editing DNA can lead to changes in physical traits, like eye color, and disease risk. Scientists use different technologies to do this. The first genome editing technologies were developed in the late 1900s. More recently, a new genome editing tool called CRISPR, invented in 2009

  • Track 20-1Genome engineering
  • Track 20-2General principles
  • Track 20-3Homology directed
  • Track 20-4Non homologous end joining

Genome editing refers to an emerging branch of biotechnology that is the realization of earlier genetic engineering technologies. Using these biotechnologies researchers are able to target specific DNA sequences and induce a double stranded break, taking advantage of recombination to create synthetic genetic content in a host genome.

 

  • Track 21-1Epigenome Editing
  • Track 21-2Artificial Transcription Factors (ATFs)
  • Track 21-3Activating Transcription
  • Track 21-4Repressing Transcription

Massive parallel DNA sequencing (synonyms are: DNA deep sequencing | DNA high-throughput sequencing | DNA-seq) includes Whole Genome Sequencing (WGS), Whole Exome Sequencing (WES or WXS) and targeted sequencing. WGS implies sequencing of the entire DNA genome, while WES focuses on sequencing only mRNA coding regions (exons) which usually represent a very minor genome fraction (3% in humans).

 

  • Track 22-1DNA Sequencing.
  • Track 22-2RNA Sequencing
  • Track 22-3Methylation Sequencing

Fragment analysis is a genetic analysis method comprising a series of techniques in which DNA fragments are fluorescently labeled, separated by capillary electrophoresis (CE), and sized by comparison to an internal standard. CE-based genetic analyzers are capable of performing both Sanger sequencing and fragment analysis. In contrast to Sanger sequencing, fragment analysis can provide sizing,

 

  • Track 23-1Sensitivity
  • Track 23-2Multiplexing
  • Track 23-3Simple preparation
  • Track 23-4Easy data analysis
  • Track 23-5Independent method

Epigenetics refers to the collective heritable changes in phenotype that arise independent of genotype. Two broad areas of epigenetics are DNA methylation and histone modifications and numerous techniques have been invented to analyze epigenetic processes not only at the level of specific genes, but also to analyze epigenetic changes that occur in defined regions of the genome as well as genome-wide

 

  • Track 24-1DNA methylation
  • Track 24-2histone modifications

The primary protein components of chromatin are histones, which bind to DNA and function as "anchors" around which the strands are wound. In general, there are three levels of chromatin organization: DNA wraps around histone proteins, forming nucleosomes and the so-called beads on a string structure (euchromatin).

 

  • Track 25-1Euchromatin
  • Track 25-2Heterochromatin

Induced pluripotent stem cells (iPSCs) are somatic cells reprogrammed into an embryonic-like pluripotent state by the expression of specific transcription factors. Despite the fact that these cells have the capacity to self-renew, they present low efficiency of reprogramming Recent studies have demonstrated that the previous somatic epigenetic signature is a limiting factor in iPSC performance.

 

  • Track 26-1Somatic cell nuclear transfer
  • Track 26-2Programming by cell fusion