Epigenetic in Aging

Epigenetic changes have a large number of effects on the Aging process. At various levels these epigenetic changes occur, including decreasing the levels of the Core Histones, changes in the patterns of Histone post-translational modifications and DNA methylation, substitution of Canonical Histones with Histone Variants and changes the noncoding RNA expression (during both organismal Aging and replicative senescence). The reversible nature of epigenetic information provides exciting path for Therapeutic Intervention in Aging and age-associated diseases, including Cancer.

1. Epigenetic clock

2. Epigenetic changes in aging

3. Histone modification changes during aging

4. Transgenerational epigenetic changes that affect aging

5. DNA methylation changes during aging

 

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