Functions and consequences: development and transgenerational
Since Mendel, studies of phenotypic variation and disease risk have emphasized associations between genotype and phenotype among affected individuals in families and populations. Although this paradigm has led to important insights into the molecular basis for many traits and diseases, most of the genetic variants that control the inheritance of these conditions continue to elude detection.
- Enviromental influences
- Genetic factors
- Gene-environment interactions
- Frequency, magnitude & persistence
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