Jiangwen Zhang
Principal investigator
The University of Hong Kong
Hong Kong
Biography
Dr. Zhang graduated from Johns Hopkins University with PhD. He has worked at Harvard University Genome Centre as Senior System Biologist for years before joining University of Hong Kong in 2013. Dr. Zhang lab has broad interest in the interaction between genetics and epigenetics components, and its implications in tumorigenesis (Nature Immunology 2012). Epigenetic factors, such as chromatin-remodelers, epigenetics enzymes, and non-coding RNA, are key players to shape epigenetic landscape. His lab has made some breakthrough recently in cancer (epi)genetics, such as systematically cataloguing all of the chromatin regulators involved in tumorigenesis (Nucleic Acids Res 2017), developing a novel method to identify chromatin regulators (CRs) functioning as tumorigenesis driver, building a computer server to identify cancer master regulators, identifying a liver cancer stemness subtype regulated by a core microRNA regulatory circuitry, and characterizing DNA methylation at enhancer with causal effects on tumorigenesis (papers under revision).
Research Interest
genetic and epigenetic regulation in development and diseases