Ermias Sisay Chanie
Debre Tabor University, Ethiopia
Title: Impact of Respiratory distress syndrome and perinatal asphyxia on the survival of preterm neonates in in East Africa context: a systematic review and meta-analysis
Biography
Biography: Ermias Sisay Chanie
Abstract
Background: Preterm incidence increased rapidly and its disproportionate contribution to increased infant
mortality rates in Africa. Hence, the aim of this systematic review and meta-analysis was to determine the
pooled mortality rate and associated contributing factors with decreasing the survival of preterm.
Methods: PubMed, Google Scholar, Hinary, Cochrane library, research gate, and institutional repositories
were retrieved were used to identity eligible articles through Preferred Reporting Items for Systematic
Review and Meta-Analysis (PRISMA) guidelines. Data was extracted in the excel sheet considering mortality
rate, and stratified the associated factors with mortality, then the data exported to STATA 14 for further
analysis. I2 and Egger’s test were estimated to the heterogeneity and publication bias of the included article
respectively. Subgroup analysis-based country, year, study design, year of publication, and sample size were
also examined.
Result: This meta-analysis included 32 articles with total of 21,405 study participants. The pooled mortality
rate among preterm in Easter Africa found to be 19.2% (95%CI; 16.0–22.4). Regarding to study design,
the mortality rate found to be 18.1%, 19.4%, and 19.7% with respect to prospective cohort, retrospective
cohort, and cross-sectional studies. The pooled odds of mortality among preterm with respiratory distress
syndrome decreased the survival by nearly three folds [AOR=3.2; 95% CI: 22, 4.6] when compared to those
who didn’t have respiratory distress syndrome. Similarly, preterm presented with birth asphyxia nearly
three times higher a risk death as compared with their counterparts [AOR=2.6; 95% CI: 1.9, 3.4].
Conclusion: Mortality of preterm was unacceptably high in Eastern Africa. Fortunately, the main causes
of death were found to be respiratory distress syndrome and birth asphyxia, which are preventable and
treatable hence early detection, and timely management of these risk factors is crucial to decrease preterm
mortality significantly