Immunology in the epigenetic era

   There are several evidence showing that loss of epigenetic control over complex immune processes contributes to autoimmune disease. Abnormal DNA methylation has been observed in patients with lupus whose T cells exhibit decreased DNA methyltransferase activity & hypomethylated DNA. Disregulation of this pathway apparently leads to overexpression of methylation-sensitive genes such as the leukocyte function-associated factor (LFA1), which causes lupus-like autoimmunity.

 

  • Systemic lupus erythematosus
  • Rheumatoid arthritis
  • Systemic sclerosis
  • Sjogren’s syndrome
  • Autoimmune thyroid diseases (AITD)

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